Highlights
- •Congenital cytomegalovirus (CMV) is the most common congenital infection and the leading cause of nongenetic sensorineural hearing loss in children.
- •Congenital CMV is associated with cognitive deficits, developmental delays, and sensorineural hearing loss, but recognition is often delayed by parents and providers.
- •A case of congenital CMV infection resulting in neurodevelopmental delays and sensorineural hearing loss is presented.
Abstract
Congenital cytomegalovirus (CMV) infection is the most common intrauterine infection
and is the leading nongenetic cause of sensorineural hearing loss and neurodevelopmental
delays in the pediatric population. Despite its high prevalence and significant sequelae,
congenital CMV in the pregnant woman and neonate often goes undiagnosed. We present
the case of a 23-month-old child presenting with developmental delays and bilateral
sensorineural hearing loss as a result of CMV and describe with this case report the
clinical features, diagnosis, testing, management, and prognosis of congenital CMV.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The Journal for Nurse PractitionersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cytomegalovirus infection and inflammation in developing brain.Viruses. 2021; 13: 1078https://doi.org/10.3390/v13061078
- Congenital cytomegalovirus infection.BMJ. 2021; 373: n1212https://doi.org/10.1136/bmj.n1212
- Congenital cytomegalovirus and hearing loss.J Obstet Gynecol Neonatal Nurs. 2020; 49: 293-304https://doi.org/10.1016/j.jogn.2020.02.005
- Healthcare Provider Information and Resources.https://www.nationalcmv.org/resources/for-healthcare-professionalsDate accessed: May 26, 2022
- Overview of human cytomegalovirus pathogenesis.Methods Mol Biol. 2021; 2244: 1-18https://doi.org/10.1007/978-1-0716-1111-1_1
- Cytomegalovirus (CMV) and Congenital CMV Infection.https://www.cdc.gov/cmv/clinical/congenital-cmv.htmlDate accessed: May 26, 2022
- Hearing loss and congenital CMV infection: a systematic review.Pediatrics. 2014; 134: 972-982
- Long-term outcomes of children with symptomatic congenital cytomegalovirus disease.J Perinatol. 2017; 37: 875-880https://doi.org/10.1038/jp.2017.41
- Diagnosis and management of infants with congenital cytomegalovirus infection.Paediatr Child Health. 2017; 22: 72-74https://doi.org/10.1093/pch/pxx002
- Advisory Committee on Heritable Disorders in Newborns and Children. Recommended Uniform Screening Panel. As of August 2022.https://www.hrsa.gov/advisory-committees/heritable-disorders/ruspDate accessed: December 28, 2022
- National CMV Foundation Nominates Congenital CMV for RUSP Newborn Screening. April 2019.https://www.nationalcmv.org/resources/blog/april-2019/national-cmv-foundation-nominates-congenital-cmv-fDate accessed: December 28, 2022
- National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Valganciclovir for symptomatic congenital cytomegalovirus disease.N Engl J Med. 2015; 372: 933-943https://doi.org/10.1056/NEJMoa1404599
- Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy.Lancet Infect Dis. 2017; 17: e177-e188https://doi.org/10.1016/S1473-3099(17)30143-3
- Valganciclovir is beneficial in children with congenital cytomegalovirus and isolated hearing loss.J Pediatr. 2018; 199: 166-170https://doi.org/10.1016/j.jpeds.2018.02.028
- A Clinical Trial of a Cytomegalovirus (CMV) Infection in Healthy Women 16 to 40 Years of Age. Moderna Clinical Trials. 2020.https://trials.modernatx.com/study/?id=mRNA-1647-P301Date accessed: December 28, 2022
Biography
Michelle P. Zappas, DNP, FNP-BC is a clinical associate professor in the Department of Nursing at the Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, and can be contacted at [email protected]
Biography
Sharon P. O'Neill, DNP, JD, FNP-BC, PMHNP-BC, is a clinical associate professor at the New York University Rory Meyers College of Nursing, New York.
Biography
Courtney Rotz, MSN, FNP-BC, is an adjunct professor in the Department of Nursing at the Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles.
Article info
Publication history
Published online: February 21, 2023
Footnotes
In compliance with standard ethical guidelines, the authors report no relationships with business or industry that would pose a conflict of interest.
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
