Highlights
- •Cystatin C is a low-molecular-weight protein found in all tissues in the body.
- •Cystatin C is freely filtered at the glomerulus and metabolized in the proximal tubule.
- •Cystatin C used in equations to estimate the glomerular filtration rate provides a more accurate assessment of kidney function compared with serum creatinine.
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References
- A unifying approach for eGFR: recommendations of the NKF-ASN Task Force on reassessing the inclusion of race in diagnosing kidney disease.Am J Kidney Dis. 2022; 79: 268-288https://doi.org/10.1053/j.ajkd.2021.08.003
- CKD Epidemiology Collaboration. New creatinine- and cystatin C-based equations to eGFR without race.N Engl J Med. 2021; 385: 1737-1749https://doi.org/10.1056/NEJMoa210953
- GFR estimation from physiology to public health.Am J Kidney Dis. 2014; 63: 820-834https://doi.org/10.1053/j.ajkd.2013.12.006
- Cystatin C: a primer for pharmacists.Pharmacy (Basel). 2020; 8: 35
- Assessment of cystatin c level for risk stratification in adults with chronic kidney disease.JAMA Netw Open. 2022; 5e2238300https://doi.org/10.1001/jamanetworkopen.2022.38300
- Advantages, limitations, and clinical considerations in using cystatin C to eGFR.Kidney360. 2022; 3: 1807-1814https://doi.org/10.34067/KID.0003202022
Biography
Department Editor Timothy Nguyen, PharmD, MBA, BCPS, FASCP, is a professor of pharmacy practice at The Arnold & Marie Schwartz College of Pharmacy and Health Sciences at Long Island University in Brooklyn, NY. He can be reached at [email protected] and would like to hear your ideas for future columns.
Article info
Publication history
Published online: February 25, 2023
Footnotes
In compliance with standard ethical guidelines, the author reports no relationships with business or industry that may pose a conflict of interest.
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
