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Effects of rTMS in Postpartum Depression: A Meta-Analysis

Published:December 01, 2022DOI:https://doi.org/10.1016/j.nurpra.2022.10.017

      Highlights

      • Repetitive transcranial magnetic stimulation (rTMS) has beneficial effects on depression and cognitive performance in patients with postpartum depression (PPD).
      • Curative effects of rTMS attributable to distinctive parameters are observed for PPD patients.
      • The optimal stimulation protocols of rTMS for PPD have initially been ascertained.

      Abstract

      The purpose of this meta-analysis is to evaluate the beneficial effects and ascertain the optimal stimulation protocol of repetitive transcranial magnetic stimulation (rTMS) on patients with postpartum depression (PPD). We performed a comprehensive literature search for randomized clinical trials through September 2022. On the basis of the inclusion criteria, 23 studies were selected for the analysis. The results of our meta-analysis showed that rTMS produced significant effects. Among the studies included in the meta-analysis, the scales used to measure PPD in the participants included the Hamilton Depression Scale (standardized mean differences [SMD] = −0.90; P < 0.05), Edinburgh Postnatal Depression Scale (SMD = −1.05; P < 0.05), Mini-Mental State Examination (SMD = 2.88; P < 0.05), and quality-of-life scores (SMD = 1.81; P < 0.05). Furthermore, rTMS was found to exert a beneficial effect on depression and cognitive performance in PPD patients with distinct optimal stimulation parameters.

      Keywords

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      Biography

      Tao Wang, MS, Physician, People’s Hospital of Leshan, Leshan, China and can be contacted at [email protected] Hongxia Wu, MS, Physician, Department of Radiology, Hospital of Traditional Chinese Medicine of Leshan, Leshan, China.

      Biography

      Yi Jiang, MD, Senior associate consult, National Clinical Research Center for Geriatrics, The West China Hospital of Sichuan University, Chengdu, China.

      Biography

      Wei Huang, MS, Attending Physician, Dong Yu, MD, Chief Physician, and Xiao Zhang, MS, Chief Physician, Department of Radiology, People’s Hospital of Leshan, Leshan, China.

      Biography

      Qiwen Mu, MD, PhD, Professor and senior consult, Institute of Rehabilitation and Imaging of Brain Function, Nanchong Central Hospital, Nanchong, China, and Department of Radiology, Peking University Third Hospital, Beijing, China.