Case Report| Volume 19, ISSUE 2, 104484, February 2023

A Rare Case of MDMA-Induced Hyponatremia

Published:November 19, 2022DOI:


      • Use of psychedelic drugs, including 3,4 methylenedioxymethamphetamine (MDMA; aka “Ecstasy” or “Molly”) is increasing as emerging research suggests they may be effective treatments for mental health concerns, including depression, anxiety, posttraumatic stress disorder, and addiction
      • Hyponatremia is a rare adverse effect of MDMA use.
      • Hyponatremia may have serious complications if not treated quickly and appropriately. Treatment differs depending on cause, symptoms, and severity.


      Hyponatremia is a common, potentially serious problem encountered in primary, acute, and critical care settings. Proper treatment requires an understanding of the multiple possible causes of hyponatremia. This case report presents an unusual cause of hyponatremia—3,4 methylenedioxymethamphetamine (MDMA; “Ecstasy” or “Molly”) use. With encouraging research emerging on the use of psychedelic drugs to treat depression, anxiety, posttraumatic stress disorder, and addiction, nurse practitioners should increase their knowledge about the evolution of MDMA from a recreational drug to a potential medicine for the care of people with serious and persistent mental health concerns.


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      Carolina Dorsen, PhD, FNP-BC, is an associate professor and associate dean, Rutgers University School of Nursing, Newark, NJ, and can be contacted at [email protected]


      Andrew Penn, MS, PMHNP-Bc, is an associate professor of Community Health Systems University of California, San Francisco School of Nursing.


      Natasha Carew, DNP, ACNP-BC, is an assistant professor at Rutgers University School of Nursing, Newark, NJ.


      Madeleine Lloyd, PhD, FNP-BC, PMHNP-BC, is affiliated with New York University Langone Health, New York, NY.