Highlights
- •Cardiac amyloidosis is underdiagnosed and often mistreated as heart failure.
- •Tafamidis is a transthyretin (TTR) stabilizer that inhibits its misfolding into amyloid fibrils.
- •Tafamidis lowers risk of all-cause mortality and cardiovascular-related hospitalizations.
- •Patisiran and inotersen are silencing agents that interfere with TTR mRNA in the liver, blocking the production of unstable TTR.
Abstract
Cardiac amyloidosis is an increasingly common diagnosis characterized by the deposition
of misfolded proteins in the myocardial tissue leading to progressive cardiac damage.
In this article, we present evidence regarding the pharmacological management of transthyretin
cardiac amyloidosis, focusing on medications that halt or regress disease progression.
This article provides a brief overview of the medications, such as diuretics, anticoagulants,
and antiarrhythmics, used to control symptoms of heart failure as a complication of
cardiac amyloidosis.
Keywords
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Biography
Mohamed Toufic El Hussein, PhD, NP, is a professor of nursing at the School of Nursing and Midwifery, Faculty of Health, Community & Education, Mount Royal University, Calgary, AB, Canada, and an acute care nurse practitioner, Medical Cardiology Coronary Care Unit, Rockyview General Hospital, Calgary, AB, Canada. He can be contacted at [email protected] and on Twitter @drmohamednp.
Biography
Daniel Favell, BA psychology, is a nursing student in the BN program at Mount Royal University, Calgary, AB, Canada.
Article info
Publication history
Published online: November 17, 2022
Footnotes
In compliance with standard ethical guidelines, the authors report no relationships with business or industry that would pose a conflict of interest.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
