- •Individuals with primary ovarian insufficiency commonly present with menstrual irregularity ranging from oligomenorrhea to amenorrhea.
- •Long-term sequelae include increased mortality risk, infertility, depression, and psychosexual and sexual dysfunction
- •Patients with primary ovarian insufficiency often experience a “diagnostic odyssey” that contributes to impaired health-related quality of life.
- •The constellation of physical and psychosocial sequelae of primary ovarian insufficiency necessitates an interdisciplinary and patient-centered approach to management.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.Qual Life Res. 2020; 29: 19-36https://doi.org/10.1007/s11136-019-02326-2
- Next generation sequencing should be proposed to every woman with “idiopathic” primary ovarian insufficiency.J Endocr Soc. 2021; 5: bvab032https://doi.org/10.1210/jendso/bvab032
- Consequences of premature ovarian insufficiency on women’s sexual health.Prz Menopauzalny. 2018; 17: 127-130https://doi.org/10.5114/pm.2018.78557
- Perceptions and experiences of women with premature ovarian insufficiency about sexual health and reproductive health.BMC Womens Health. 2021; 21: 54https://doi.org/10.1186/s12905-021-01197-5
- Effect of primary ovarian insufficiency and early natural menopause on mortality: a meta-analysis.Climacteric. 2016; 19: 27-36https://doi.org/10.3109/13697137.2015.1094784
- Primary ovarian insufficiency: a more accurate term for premature ovarian failure.Clin Endocrinol (Oxf). 2008; 68: 499-509https://doi.org/10.1111/j.1365-2265.2007.03073.x
- Healthcare access, satisfaction, and health-related quality of life among children and adults with rare diseases.Orphanet J Rare Dis. 2022; 17: 196https://doi.org/10.1186/s13023-022-02343-4
- Incidence of premature ovarian failure.Obstet Gynecol. 1986; 67: 604-606
- The prevalence of primary ovarian insufficiency in Sweden; a national register study.BMC Womens Health. 2018; 18: 175https://doi.org/10.1186/s12905-018-0665-2
- Clinical practice. Primary ovarian insufficiency.N Engl J Med. 2009; 360: 606-614https://doi.org/10.1056/NEJMcp0808697
- Current concepts in premature ovarian insufficiency.Womens Health (Lond). 2015; 11: 169-182https://doi.org/10.2217/whe.14.82
- Premature menopause in a multi-ethnic population study of the menopause transition.Hum Reprod. 2003; 18: 199-206https://doi.org/10.1093/humrep/deg005
- The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis.Climacteric. 2019; 22: 403-411https://doi.org/10.1080/13697137.2019.1574738
- EMAS position statement: predictors of premature and early natural menopause.Maturitas. 2019; 123: 82-88https://doi.org/10.1016/j.maturitas.2019.03.008
- Menopause. Nat Rev Dis Primers. 2015; 1: 15004https://doi.org/10.1038/nrdp.2015.4
- Male and female hypogonadism.Nurs Clin North Am. 2018; 53: 395-405https://doi.org/10.1016/j.cnur.2018.04.006
- Premature ovarian insufficiency: a toolkit for the primary care physician.Maturitas. 2021; 147: 53-63https://doi.org/10.1016/j.maturitas.2020.11.004
- Premature ovarian insufficiency—an update on recent advances in understanding and management.F1000Res. 2017; 6: 2069https://doi.org/10.12688/f1000research.11948.1
- Diagnosis and management of premature ovarian insufficiency.Best Pract Res Clin Endocrinol Metab. 2021; 35: 101600https://doi.org/10.1016/j.beem.2021.101600
- Impact of a premature menopause on cognitive function in later life.BJOG. 2014; 121: 1729-1739https://doi.org/10.1111/1471-0528.12828
- Progressive changes in LH and FSH and LH:FSH ratio in women throughout reproductive life.Maturitas. 1988; 10: 35-43https://doi.org/10.1016/0378-5122(88)90129-6
- Does an association exist between menstrual cycle length within the normal range and ovarian reserve biomarkers during the reproductive years? A systematic review and meta-analysis.Hum Reprod Update. 2020; 26: 904-928https://doi.org/10.1093/humupd/dmaa013
- International statistical classification of diseases and related health problems.10th ed. 2019https://icd.who.int/browse10/2019/en#/Date accessed: September 12, 2022
- Fragile X syndrome.Nat Rev Dis Primers. 2017; 3: 17065https://doi.org/10.1038/nrdp.2017.65
- Genetic competencies for effective pediatric endocrine nursing practice.J Pediatr Nurs. 2019; 48: 127-128https://doi.org/10.1016/j.pedn.2019.06.006
- 698: hormone therapy in primary ovarian insufficiency.Obstet Gynecol. 2017; 129: e134-e141https://doi.org/10.1097/aog.0000000000002044
- ESHRE Guideline: management of women with premature ovarian insufficiency.Hum Reprod. 2016; 31: 926-937https://doi.org/10.1093/humrep/dew027
- Treatment of symptoms of the menopause: an Endocrine Society Clinical Practice Guideline.J Clin Endocrinol Metab. 2015; 100: 3975-4011https://doi.org/10.1210/jc.2015-2236
- Estrogen-based hormone therapy in women with primary ovarian insufficiency: a systematic review.Endocrine. 2017; 58: 413-425https://doi.org/10.1007/s12020-017-1435-x
- Premature ovarian insufficiency: the context of long-term effects.J Endocrinol Invest. 2016; 39: 983-990https://doi.org/10.1007/s40618-016-0467-z
- Assessing the emotional needs of women with spontaneous premature ovarian failure.Fertil Steril. 2005; 83: 1734-1741
- An exploration of factors affecting the quality of life of women with primary ovarian insufficiency: a qualitative study.BMC Womens Health. 2020; 20: 163https://doi.org/10.1186/s12905-020-01029-y
- Influence of sexual function on the social relations and quality of life of women with premature ovarian insufficiency.Rev Bras Ginecol Obstet. 2018; 40: 66-71https://doi.org/10.1055/s-0037-1615289
- Psychosocial vulnerability, resilience resources, and coping with infertility: a longitudinal model of adjustment to primary ovarian insufficiency.Ann Behav Med. 2016; 50: 272-284https://doi.org/10.1007/s12160-015-9750-z
- Depression in women with spontaneous 46, XX primary ovarian insufficiency.J Clin Endocrinol Metab. 2011; 96: E278-E287https://doi.org/10.1210/jc.2010-0613
- Lifelong estradiol exposure and risk of depressive symptoms during the transition to menopause and postmenopause.Menopause. 2017; 24: 1351-1359
- Association between physical activity and risk of depression: a systematic review and meta-analysis.JAMA Psychiatry. 2022; 79: 550-559https://doi.org/10.1001/jamapsychiatry.2022.0609
- Women’s experiences of diagnosis and treatment of early menopause and premature ovarian insufficiency: a qualitative study.Semin Reprod Med. 2020; 38: 247-255https://doi.org/10.1055/s-0040-1721463
- What are models of care? A systematic search and narrative review to guide development of care models for premature ovarian insufficiency.Semin Reprod Med. 2020; 38: 323-330https://doi.org/10.1055/s-0041-1726131
- A design thinking approach to primary ovarian insufficiency.Panminerva Med. 2017; 59: 15-32https://doi.org/10.23736/S0031-0808.16.03259-6
- Dissemination, implementation and impact of the ESHRE evidence-based guidelines.Hum Reprod Open. 2019; 2019: hoz011https://doi.org/10.1093/hropen/hoz011
- Premature ovarian insufficiency–aetiopathology, epidemiology, and diagnostic evaluation.Prz Menopauzalny. 2018; 17: 105-108
Publication stageIn Press Corrected Proof
In compliance with standard ethical guidelines, the author reports no relationships with business or industry that would pose a conflict of interest.
This work was supported by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development (1P50HD104224-01) “Massachusetts General Hospital – Harvard Center for Reproductive Medicine”.