- •Individuals with primary ovarian insufficiency commonly present with menstrual irregularity ranging from oligomenorrhea to amenorrhea.
- •Long-term sequelae include increased mortality risk, infertility, depression, and psychosexual and sexual dysfunction
- •Patients with primary ovarian insufficiency often experience a “diagnostic odyssey” that contributes to impaired health-related quality of life.
- •The constellation of physical and psychosocial sequelae of primary ovarian insufficiency necessitates an interdisciplinary and patient-centered approach to management.
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In compliance with standard ethical guidelines, the author reports no relationships with business or industry that would pose a conflict of interest.
This work was supported by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development (1P50HD104224-01) “Massachusetts General Hospital – Harvard Center for Reproductive Medicine”.