- •Glycol intoxication may lead to delayed neurologic manifestations, which may lead to an inaccurate diagnosis.
- •The traditional laboratory investigation may not indicate ethylene glycol exposure if preformed too soon after ingestion because the anion gap acidosis takes time to develop.
- •Initial treatment is to maintain the airway, breathing, and circulation while minimizing the toxic load.
- •Aggressive hydration with crystalloid solution (normal saline) to enhance urinary output as well as sodium bicarbonate infusion to correct metabolic acidosis are the primary aims.
- •The Food and Drug Administration–approved antidote for ethylene glycol toxicity is fomepizole (Antizol) given every 12 hours intravenously.
- •Clinicians should be aware that the use of corticosteroids is not an Food and Drug Administration–approved treatment for the late effect of cranial nerve deficit caused by glycol toxicity.
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