The Journal for Nurse Practitioners
Volume 6, Issue 7 , Pages 507-516 , July 2010

Genetics and Disease Prevention: Complementary or Contradictory?

  • Diane C. Seibert

      Affiliations

    • Diane C Seibert, PhD, CRNP, FAANP, is an associate professor and director of the family nurse practitioner program at Uniformed Services University of the Health Sciences in Bethesda, MD.

References 

  1. Peck P , Cox L . The top 10 medical advances of the decade: from genome to hormones, doctors pick the top medical advances of the decade. ABC News in collaboration with MedPage Today . Available at: http://abcnews.go.com/Health/Decade/genome-hormones-top-10-medical-advances-decade/story?id=9356853 Dec 17, 2009; Accessed Feb25, 2010.
  2. Darr AS . Vision of a personal genomics future . Nature . 2010;643(21):298–299
  3. National Center for Biotechnology Information  . International HapMap project . Available at: http://hapmap.ncbi.nlm.nih.gov/whatishapmap.html Accessed Feb 28 2010.
  4. Lamberts SW , Uitterlinden AG . Genetic testing in clinical practice . Annu Rev Med . 2009;60:431–442
  5. Heron M, Hoyert DL, Murphy SL, Xu J, Murphy S, Xu J, et al. Deaths: final data for 2006. National vital statistics reports, vol 57(14). Hyattsville, MD: National Center for Health Statistics; 2009 . Available at: http://www.cdc.gov/nchs/data/nvsr/nvsr57/nvsr56_14.pdf
  6. US Department of Health and Human Services  . Healthy people 2010: understanding and improving health. Dept of Health and Human Services . 2nd ed.. Washington DC: US Government Printing Office; 2000;
  7. Whitehead D . Health promotion and health education: advancing the concepts . J Adv Nurs . 2004;47(3):311–320
  8. Breslow L . From disease prevention to health promotion . JAMA . 1999;281(11):1030–1033
  9. Berg AO, Baird MA, Botkin JR, et al. Panel statement. Paper presented at the NIH State-of-the-Science Conference: Family History conference. Bethesda, MD: 2009.
  10. Qureshi N , Wilson B , Santaguida P , et al.   In: Evidence report/technology assessment no. 186. Presented at the NIH State-of-the-Science Conference: Family History and Improving Health . Rockville, MD: Agency for Healthcare Research and Quality Publication no. 09; 2009;p. 16
  11. Borgmeyer C . Wired for education: AAFP takes major CME initiative to the Web . J Adv Nurs . 2005;3(3):277–278
  12. American Cancer Society  . Cancer facts and figures 2009 . Altanta, GA: American Cancer Society; 2009;
  13. Snustad DP , Simmons MJ . Principles of genetics . 3rd ed.. New York, NY: John Wiley & Sons, Inc.; 2003;
  14. Wolff AC , Hammond ME , Schwartz JN , et al.   American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer . J Clin Oncol . Jan 1 2007;25(1):118–145
  15. Tsoi DT , Inoue M , Kelly CM , Verma S , Pritchard K . Cost-effectiveness analysis of oncotype DX-guided treatment in early breast cancer . J Clin Oncol . 2009;27(May 20 suppl):15S
  16. Ellingrod VL , Moline J . Incorporating pharmacogenomics into practice . J Pharm Pract . 2007;20(3):277–282
  17. Rieder MJ , Reiner AP , Gage BF , et al.   Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose . N Engl J Med . 2005;352(22):2285–2293
  18. Wu AH . Pharmacogenomic testing for warfarin dosing: we are ready now . Expert Rev Cardiovasc Ther . 2009;7(12):1483–1485
  19. US Food and Drug Administration  . MedWatch: Warfarin (marketed as Coumadin). 2007 . Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm152972.htm Accessed Feb 27 2007.
  20. Franceschini N , Rose KM , Storti KL , et al.   Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study . Circ Cardiovasc Genet . 2009;2(4):396–401
  21. Bouchard C . Defining the genetic architecture of the predisposition to obesity: a challenging but not insurmountable task . Am J Clin Nutr . 2010;91(1):5–6
  22. Zhu H , Finnell RH . Update on gene-environment interactions and birth defects . Female Patient . 2010;35:27–30
  23. van der Put NMJ , van Straaten HWM , Trijbels FJM , Blom HJ . Folate, homocysteine and neural tube defects: an overview . Exp Biol Med . 2001;226(4):243–270
  24. Committee on Genetics  . Folic acid for the prevention of neural tube defects . Pediatrics . 1999;104(2):325–327
  25. Beckmann CRB , Ling FW , Barzansky BM , Herbert WNP , Laube DW , Smith RP . Obstetrics and gynecology . 6th edition. Lippincott Williams & Wilkins; 2009;
  26. Tam WH , Ma RC , Yang X , et al.   Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero . Pediatrics . 2008;122(6):1229–1234
  27. Pierpont ME , Basson CT , Benson DW , et al.   Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics . Circulation . 2007;115(23):3015–3038
  28. Jenkins KJ , Correa A , Feinstein JA , et al.   Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics . Circulation . 2007;115(23):2995–3014
  29. Metsios GS , Flouris AD , Koutedakis Y . Passive smoking, asthma and allergy in children . Inflamm Allergy Drug Targets . 2009;8(5):348–352
  30. Li YF , Langholz B , Salam MT , Gilliland FD . Maternal and grandmaternal smoking patterns are associated with early childhood asthma . Chest . 2005;127(4):1232–1241
  31. Association of State and Territorial Health Officials  . Newborn screening position statement, September 29, 2009 . Available at: http://www.astho.org/Display/AssetDisplay.aspx?id=2867
  32. Driggers R , Seibert D . Prenatal screening: new guidelines, new challenges . J Nurs Pract . 2008;4(5):351–356
  33. Adams PC . The natural history of untreated HFE-related hemochromatosis . Acta Haematol . 2009;122(2–3):134–139
  34. Bird A . Perceptions of epigenetics . Nature . 2007;447(7143):396–398
  35. Saslow R. Epigenetics research takes aim at cancer, Alzheimer's, autism, other illnesses: research on mice might have meaning for many human illnesses. Washington Post. Dec 15, 2009, p H5
  36. Gill SR , Pop M , Deboy RT , et al.   Metagenomic analysis of the human distal gut microbiome . Science . 2006;312(5778):1355–1359
  37. Turnbaugh PJ , Ley RE , Mahowald MA , Margrini V , Mardis ER , Gordon JI . An obesity-associated gut microbiome with increased capacity for energy harvest . Nature . 2006;444(21):1027–1031
  38. Nightengale F. Notes on nursing: what it is, and what it is not. 1859.

 The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, the Uniformed Services University, the Department of Defense, or the US government.This continuing education activity is designed to augment the knowledge, skills, and attitudes of nurses and nurse practitioners regarding the use of genetics in primary care.At the conclusion of this activity, the participant will be able to:

a.Identify genetic red flags in the family history

b.Describe how genetics is used to improve patient outcomes in primary care

c.List 4 examples of future applications of genetic knowledge in primary care

The authors, reviewers, editors, nurse planners, and pilot testers all report no financial relationships that would pose a conflict of interest.The authors do not present any off-label or non-FDA approved recommendations for treatment.There is no implied endorsement by NPA or ANCC of any commercial products mentioned in the article.

PII: S1555-4155(10)00212-6

doi: 10.1016/j.nurpra.2010.04.002

The Journal for Nurse Practitioners
Volume 6, Issue 7 , Pages 507-516 , July 2010

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