The Journal for Nurse Practitioners
Volume 6, Issue 7 , Pages 519-523 , July 2010

Are We Missing Vitamin B12 Deficiency in the Primary Care Setting?

  • Rebecca Hilgen Bryan

      Affiliations

    • Rebecca Hilgen Bryan, MSN, APRN, is a lecturer in the family health nurse practitioner program at the University of Pennsylvania School of Nursing, Philadelphia, PA, and a nurse practitioner at Wolfe-Simon Medical Associates, PA, in Cherry Hill, New Jersey.

References 

  1. Balducci L . Epidemiology of anemia in the elderly: information on diagnostic evaluation . J Am Geriatr Soc . 2003;51(3s):2–9
  2. Forster S , Gariballa S . Age as a determinant of nutritional status: a cross sectional study . Nutr J . 2005;4
  3. Kumar N . Neurologic presentations of nutritional deficiencies . Neurol Clin . 2010;28:107–170
  4. Wang Y , Yan F , Zhang W , et al.   An investigation of vitamin B12 deficiency in elderly inpatients in neurology department . Neurosci Bull . 2009;25(4):209–215
  5. Hemmer B , Glocker FX , Schumacher M , et al.   Subacute combined degeneration: clinical eletrophysiological, and magnetic resonance imaging findings . J Neurol Neurosurg Psychiatr . 1998;65(6):822–827
  6. Green R , Kinsella LJ . Current concepts in the diagnosis of cobalamin deficiency . Neurology . 1995;45:1435
  7. McLean RR , Jacques PF , Selhub J , et al.   Plasma B vitamins, homocysteine and their relation to bone loss and hip fracture in elderly men and women . J Clin Endocrinol Metab . 2008;93(6):2206–2212
  8. Lu SY , Wu HC . Initial diagnosis of anemia from sore mouth and improved classification of anemias by MCV and RDW in 30 patients . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2004;98(6):679–685
  9. Volkov I , Rudoy I , Press Y . Successful treatment of chronic erythema nodosum with vitamin B12 . J Am Board Fam Pract . 2005;18(6):567–569
  10. Morris MS , Jacques PF , Rosenberg IH , et al.   Folate and vitamin B12 status in relation to anemia, macrocytosis and cognitive impairment in older Americans in the age of folic acid fortification . Am J Clin Nutr . 2007;85(1):193–200
  11. Andres E , Loukili NH , Noel E , et al.   Vitamin B12 (cobalamin) deficiency in elderly patients . CMAJ . 2004;171(3):251–259
  12. Marcuard SP , Albernaz L , Khazanic PG . Omeprazole therapy causes malabsorption of cyanocobalamin . Am Intern Med . 1994;120(3):211–215
  13. Shah M , Simha V , Garg A . Review: long-term impact of bariatric surgery on body weight, comorbidities and nutritional status . J Clin Endocrinol Metab . 2006;91(11):4223–4231
  14. Bauman WA , Shaw S , Jayatilleke E , et al.   Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin . Diabetes Care . 2000;23(9):1227–1231
  15. Rodriguez RM , Corwin HL , Gettinger A , et al.   Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness . J Crit Care . 2001;16(1):36–41
  16. Ullegauldi R , Powers HJ , Gariballa SE . B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke . Clin Sci . 2004;107(5):477–484
  17. Dickey W . Low serum vitamin B12 is common in celiac disease and is not due to autoimmune gastritis . Eur J Gastroenterol Hepatol . 2002;14(4):425–427
  18. Headstrom PD , Rulyak SJ , Lee SD . Prevalence of and risk factors for vitamin B12 deficiency in patients with Crohn's disease . Inflamm Bowel Dis . 2008;14(2):217–223
  19. Nettina SM . A new look at vitamin B12 deficiency . Nurs Pract . 2009;34(11):19–24
  20. Vogiatzoglou A , Oulhaj A , Smith AD , et al.   Determinants of plasma methylmalonic acid in large populations: implications for assessment of B12 status . Clin Chem . 2009;55(12):198–206
  21. McCracken C , Hudson P , Ellis R , et al.   Methylmalonic acid and cognitive function in the medical research council: cognitive function and ageing study . Am J Clin Nutr . 2006;84(6):1406–1411
  22. Mete N , Gulbahar O , Aydin A , et al.   Low B-12 levels in chronic idiopathic urticaria . J Invest Allergol Clin Immunol . 2004;14(H):292–299
  23. Ahluwalia N . Aging, nutrition and immune function . J Nutr Health Aging . 2004;8(1):2–6
  24. Varda-Moreiras G , Murphy MM , Scott JMC . Older adults are at increased risk of B12 deficiency compared with younger adults and children . Nutr Rev . 2009;67(Suppl 1):569–572
  25. Butler CC , Vidal-Alaball J , Canning-John R , et al.   Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systemic review of randomized controlled studies . Fam Pract . 2006;23(3):279–285
  26. Higdon J . Vitamin B12. Linus Pauling Institute. Micronutrient Information Center . Available at: http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/index.html
  27. McKay DL , Perrone G , Rasmussen H , et al.   The effects of multivitamin/mineral supplements on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet . J Am Col Nutr . 2000;19(5):613–621

 In compliance with national ethical guidelines, the author reports no relationships with business or industry that would pose a conflict of interest.

PII: S1555-4155(10)00064-4

doi: 10.1016/j.nurpra.2010.01.023

The Journal for Nurse Practitioners
Volume 6, Issue 7 , Pages 519-523 , July 2010