Healthy Aging: Clinical and Lifestyle Considerations
Article Outline
“The best way to age is too die young as late as possible.”—Christian Barnard, MD
Ellen Hughes, MD, PhD, began her Hot Topics presentation with a discussion of the science of healthy aging and how it can teach us to live better. Aging is a nonpathological process that affects all organisms. The average life expectancy in the United States is 78 years old. We do better than the Angolans (average 38) but worse than the Macauans (average 84). One in 5 Americans will be older than 65 by 2030. Distressingly, US life expectancy is declining in some areas because of poor health habits.
The science of aging has taught us many things. The ethnographic book Blue Zones (2010) examined people living a century or more who remained mentally and physically vibrant as they aged. Centenarian studies have investigated what qualities or behaviors (both good and bad) lead to a long life. Up to this point we have thought that aging is like wear and tear that happens to a car, but we are now finding that many other things play into that equation. One of those things is caloric restriction. Animals that eat a third fewer calories live one third longer and have less insulin resistance, delayed onset of age-related disorders, and slower decline in functional status. Human studies are now ongoing in caloric restriction.
Longevity can run in families and allow some leeway in terms of lifestyle choices. Simple gene alterations can alter lifespan in several species. Clearly, there is more than just 1 “longevity pathway,” and the science of this is still evolving. So what does this mean for your patients? Individuals are in much greater control of their health than originally thought. Health is determined by a combination of factors, including genetics (30%), social habits (15%), environment (5%), access to health care (10%), and behavior (40%).
Most interesting is that individuals have a huge amount of influence about how the genetic hand of cards gets played out. It was originally believed that you were dealt the hand you had and that was that, but now it is known that adopting a healthy lifestyle can alter how DNA is marked, packaged, and expressed. Furthermore, that change can pass down to the next generation. There are 2 heritable alterations in gene expressions caused by mechanisms other than changes in DNA sequences (methahylation of DNA and histone acetation). Also, telomeres lengthen in response to a healthy lifestyle and stress management. Healthy lifestyles have powerful effects on epigenetics.
Unfortunately, many people are not leading healthy lifestyles. A telephone study with 153,000 US adults asked just 4 questions about their health habits: did they abstain from smoking, maintain a healthy weight, eat 5 fruits and veggies a day, and exercise regularly. Only 3% answered yes to all 4 questions!
How do you help patients begin to make healthier behavior choices? In order for a behavior to be successful, it needs to be easy, integrated into lifestyle, enjoyable, and sustainable. Dr. Hughes discussed the following 10 recommendations for healthy aging. (The first 2 recommendations are discussed in depth in her lecture “Clinical Considerations for Managing Obesity,” which will be detailed in a later Hot Topics department.)
Dr. Hughes concluded her lecture with the advice to appreciate the benefits of aging. They include experience and wisdom, the gift of time, freedom from routines, and senior discounts!
Ellen Hughes, MD, PhD, is clinical professor of medicine emeritus at the University of California in San Francisco.This department is brought to you by Hot Topics in Primary Care, a Contemporary Forums conference held every August in Jackson Hole, WY. For more information on this presentation, go to http://www.contemporaryforums.com/en/Live-CEConferences/. For more information about Contemporary Forums, go to http://www.contemporaryforums.com. For content and CE please go to www.onlinecelibrary.com.
Providing Quality, Accredited Continuing Education to Thousands of Healthcare Professionals for More Than 25 Years
PII: S1555-4155(11)00514-9
doi:10.1016/j.nurpra.2011.10.002
© 2012 American College of Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

