Osteoporosis is a disorder characterized by brittle, fragile bones. It results from unbalanced bone metabolism and often leads to bone fractures and, consequently, a decreased quality of life. It is complex in pathology and requires multifactorial management and treatment. It is imperative that nurse practitioners (NPs) maintain current best-practice knowledge to appropriately manage and treat this increasingly prevalent and debilitating disease. This article provides a review of information regarding recent evidence for pharmacological and supplemental therapies in osteoporosis, including strontium ranelate, genistein, and vitamin K.